In summary, we identified 9 hub STTK genes (i.e., MYF6, AATF, AURKA, CXCL9, DPM2, MYO1B, NCBP2, TNFRSF12A, and TRAF1) that played vital functions in the tumor immunity of HNSC. This evidence concerns the gene DPM2 and neoplasm.