In summary, we identified 9 hub STTK genes (i.e., MYF6, AATF, AURKA, CXCL9, DPM2, MYO1B, NCBP2, TNFRSF12A, and TRAF1) that played vital functions in the tumor immunity of HNSC. The gene discussed is TNFRSF12A; the disease is neoplasm.