A few previous independent studies using mice genetically depleted for the whole macroH2A1 gene (without making a distinction between the isoforms macroH2A1.1 and macroH2A1.2) have shown changes in glucose tolerance32,33 in males, and exacerbated hepatic steatosis in females34. This evidence concerns the gene MACROH2A1 and Hepatic steatosis.