The top KEGG pathways of PPIA were systemic lupus erythematosus, alcoholism, neuroactive ligand-receptor interaction, calcium signaling pathway, cell cycle, pancreatic secretion, vascular smooth muscle contraction, protein digestion and absorption, progesterone-mediated oocyte maturaction, bile secretion, fat digestion and absorption, DNA replication, ascorbate and aldarate metabolism, and renin-angiotensin system (Fig. 3B). This evidence concerns the gene REN and alcohol dependence.