BRD2 and metabolic disease: Its primary function involves the modulation of transcriptional activity via the recruitment of various transcription factors, co-activators, and repressors.50 During chromatin remodeling, BRD2 recruits many proteins, such as histone deacetylases.51,52 Research has shown that BRD2 is at its peak during the development and closure of the neural tube, and it is essential for both neurogenesis and embryogenesis.53,54 Researchers have noted in recent years that BRD2 is associated with improvements in insulin signaling as well as metabolic diseases.55