DNER and Thrombocytopenia: This side effect may be related to BET inhibitors interfering with the transcription factor GATA1,57,181–183 which is known to have an essential function in maintaining red blood cell function.184,185 In clinical trials, BET inhibitor-induced thrombocytopenia was found to be reversed by stopping the therapy for one week after two consecutive weeks of oral OTX015.117,126 While it is generally seen that platelet counts tend to recover within a week after discontinuing the medication, this intermittent dosing may reduce drug efficacy and contribute to acquired drug resistance.