SPINK6 and melanoma: Through controlling SPINK6, NHWD-870 has been shown in recent studies to significantly diminish melanoma invasion and metastasis both in vivo and in vitro,122 and NHWD-870 in combination with cytarabine demonstrated synergistic effects against melanoma both in vivo and in vitro.123 NHWD-870 has also shown excellent therapeutic potential in the treatment of osteosarcoma.124 NHWD870 exhibited a favorable contraceptive effect in in vivo animal experiments, and upon discontinuation of the drug, fertility can be restored to its baseline.