TAMs are often involved in mediating the resistance of cancerous cells to platinum-based chemotherapy, anti-VEGF/VEGFR treatment, and radiotherapy,210–213 and one study discovered that TNBC-stimulated TAMs activate NF-κB signaling by upregulating IKBKE expression to increase breast carcinoma cell resistance to BET inhibitors.214 BRD4 hyperphosphorylation, which is associated with CDK9 kinase activity, has also been found in NMC and other cancers. This evidence concerns the gene BRD4 and cancer.