BRDT and Infertility: BRDt is a bromodomain protein that exhibits specificity for the testis, being expressed only within this particular organ.73,74 Studies conducted on animals have demonstrated that the absence of the BRDt protein leads to infertility, low sperm count, and abnormalities in sperm morphology.75 Cell cycle protein A1 is a crucial regulating gene in the male germline that is required for sperm cells to enter the first meiotic division, and the expression of cell cycle protein A1 is initiated and regulated by BRDt.76,77