They also found that inhibition of STAT3 affects the immune microenvironment by increasing CD3+ and CD8+ lymphocytes and promoting tumor cell immunogenic death.93 Recent research indicates that tumor-associated macrophages are crucial to the development of ovarian cancer, with high expression of BRD4 upregulating CSF1 to promote macrophage proliferation and differentiation. The gene discussed is BRD4; the disease is ovarian carcinoma.