ZDHHC3 and dilated cardiomyopathy: Notably, although zDHHC3 and zDHHC7 are appreciably expressed in many cardiac cell types, including myocytes and fibroblasts (data not shown) (48, 49), RNA-seq of isolated cardiomyocytes revealed upregulation of ZDHHC3 and ZDHHC7 transcripts in human dilated cardiomyopathy (50), implicating a pathophysiologic role for cardiomyocyte zDHHC3/7 in the heart.