ZDHHC3 and dilated cardiomyopathy: Transgenic mice on a normal diet with overexpression of Zdhhc3 starting around birth (when ventricular αMHC expression begins), but not mice overexpressing the enzymatically dead Zdhhc3DHHS mutant, exhibited substantial mortality in young adulthood due to severe dilated cardiomyopathy with a median survival of 6 weeks of age in low expressing lines (Fig. 2, D and E) and around 3 weeks of age in a high-expressing line (data not shown).