Surprisingly, TGFB1 were significantly dysregulated in almost all cancer types: it was significantly up-regulated in 17 cancer types such as AML, breast invasive carcinoma (BRCA), and cholangiocarcinoma (CHOL), whereas it was significantly down-regulated in 12 cancer types (Fig. 1D). Here, TGFB1 is linked to cholangiocarcinoma.