Subsequently, ROC curve analysis was conducted to assess the diagnostic value of urinary RNAs in the diagnosis of CKD, and the results revealed that urinary miR-542-5p, miR-33b-5p, miR-190a-3p, miR-507, and CSAG4 exhibited an AUC of 0.8750 (95% CI, 0.7552–0.9948, p < 0.001), 0.7625 (95% CI, 0.6819–0.8431, p < 0.001), 0.8438 (95% CI, 0.7764–0.9111, p < 0.001), 0.8188 (95% CI, 0.7468–0.8907, p < 0.001) and 0.7750 (95% CI, 0.6962–0.8538, p < 0.001), respectively (Fig. 6A–E). The gene discussed is CSAG4; the disease is chronic kidney disease.