ESR1 and migraine disorder: Concerning ESR1-PvuII, a significant association has been found where the allele (OR: 1.47 [1.24–1.74], I2 = 0%), dominant (OR: 1.66 [1.30–2.12], I2 = 0%), and recessive model (OR: 1.91 [1.31–2.77], I2 = 0%) significantly increase the risk of migraine.