Strikingly, preliminary bioinformatics analysis found there was a putative binding target of miR-493-5p on the 3′-UTR regions of Mef2c. Previous literature revealed that single nucleotide polymorphism (SNP) of Mef2c gene locus was greatly correlated to adult osteoporosis and osteoporotic fractures24. Here, MEF2C is linked to osteoporosis.