For evaluating the distribution of SAA protein in different LUAD subpopulation we used patient derived organoids (Fig. 1E, F), in tumor organoids we first identified Pan-CK+/CD133+/CD44+/CD24- population as primitive cancer stem population, and in intracellular staining we observed significantly higher level of SAA signal in cancer stem population (Fig. 1G). The gene discussed is CD44; the disease is cancer.