To explore the biological impact of SAA signal in the context of anti-tumor immunity, we established an autologous ex-vivo organoids-PBMCs co-culture model, as shown in Fig. 3A the fresh tumor and peripheral blood were collected from LUAD patients for tumor organoids culturing and PBMCs isolation, and the isolated PBMCs were first cryopreserved. This evidence concerns the gene SAA1 and neoplasm.