But it’s unclear which receptor is dominating the SAA induced stemness transformation and type 2 immunity in the contest of lung cancer, thus we introduced siRNAs knockdown P2X7 and FPR2 (knockdown efficiency data in Fig. S6B) and TIRAP inhibitor (TIRAP is an adapter molecule associated with toll-like receptors) [31]. The gene discussed is TIRAP; the disease is lung carcinoma.