In particular, the T cell activation genes Rac2 [33] and Igf1 [34] were increased while the malignant tumor-associated genes Mgl2 [35], Tnfrsf9 [36], Vegfa [37] as well as the M2 macrophage markers Retnla and Arg-1 were decreased (Fig. 3C). The gene discussed is IGF1; the disease is cancer.