The proliferation of PY8119 cells in vitro was not enhanced by TLR2−/− M2 BMDM and could not be inhibited by PepO-primed TLR2−/− M2 BMDM, while TLR4−/− M2 BMDM promoted tumor cell proliferation and this could be inhibited by PepO reprograming (Additional file 1: Fig S5F). The gene discussed is TLR2; the disease is neoplasm.