Tumor cell proliferation in TLR2−/− mice was not promoted because they lacked M2 macrophages while TLR4−/− mice displayed a reduced tumor cell proliferation in response to PepO treatment owing to PepO could prevent TLR4 deficient macrophages from tumor-promoting M2 phenotype (Additional file 1: Fig S5B). The gene discussed is TLR2; the disease is neoplasm.