Furthermore, treating with 2-D08 or overexpressing SUMO-specific peptidase 3 (SENP3), a SUMO protease mainly dissociating SUMO2 from substrates,25 significantly suppressed the attachment of SUMO2 to hnRNPA2B1 (Fig. 4c), confirming that hnRNPA2B1 is SUMOylated with SUMO2 in NSCLC cells. The gene discussed is SENP3; the disease is non-small cell lung carcinoma.