HNRNPA2B1 and non-small cell lung carcinoma: Furthermore, treating with 2-D08 or overexpressing SUMO-specific peptidase 3 (SENP3), a SUMO protease mainly dissociating SUMO2 from substrates,25 significantly suppressed the attachment of SUMO2 to hnRNPA2B1 (Fig. 4c), confirming that hnRNPA2B1 is SUMOylated with SUMO2 in NSCLC cells.