HNRNPA2B1 and non-small cell lung carcinoma: Considering that SUMOylated hnRNPA2B1 was crucial in packaging circTLCD4-RWDD3 into NSCLC cells-derived EVs, we investigated the effect of impairing hnRNPA2B1 SUMOylation on tube formation and migration of HLECs facilitated by EV-packaged circTLCD4-RWDD3.