PDCD6IP and non-small cell lung carcinoma: Transwell migration and tube formation assays revealed that EVs derived from circTLCD4-RWDD3-overexpressing NSCLC cells notably enhanced lymphangiogenesis in vitro, whereas mutation of SIM in ALIX reversed the lymphangiogenesis induced by EV-packaged circTLCD4-RWDD3 (Supplementary Fig. 6j), suggesting that ALIX SIM acts crucial role in EV-packaged circTLCD4-RWDD3-induced lymphangiogenesis in vitro.