Moreover, blocking the transportation of EV-packaged circTLCD4-RWDD3 by impairing hnRNPA2B1 SUMOylation or mutating ALIX SIM in NSCLC cells inhibited NSCLC lymphangiogenesis and LN metastasis in vitro and in vivo. Here, HNRNPA2B1 is linked to non-small cell lung carcinoma.