PDCD6IP and non-small cell lung carcinoma: The results showed that knocking down ALIX greatly decreased the expression levels of circTLCD4-RWDD3 and hnRNPA2B1 in NSCLC cell-derived EVs without affecting the expression of hnRNPA2B1 in NSCLC cells (Fig. 5j–l), confirming that ALIX is involved in mediating the loading of circTLCD4-RWDD3 and hnRNPA2B1 into NSCLC cell-secreted EVs.