Together, these findings indicate that unregulated circTLCD4-RWDD3 increases UBC9 expression to induce the SUMOylation of hnRNPA2B1 and enhance its sorting into EVs, eventually enhancing lymphangiogenesis and LN metastasis of NSCLC (Fig. 9). The gene discussed is HNRNPA2B1; the disease is non-small cell lung carcinoma.