PDCD6IP and non-small cell lung carcinoma: In summary, our study has illuminated a novel mechanism by which SUMOylated hnRNPA2B1 promotes ALIX activation to facilitate the packaging of circTLCD4-RWDD3 into EVs by interacting with the SIM motif in ALIX, resulting in the lymphangiogenesis and LN metastasis in NSCLC.