Chromatin immunoprecipitation (ChIP) assays showed that the enrichment of hnRNPA2B1 and H3K4me3 on UBC9 promoter were significantly increased in circTLCD4-RWDD3-overexpressing NSCLC cells, and knocking down circTLCD4-RWDD3 impeded the enrichment of hnRNPA2B1 and H3K4me3 on UBC9 promoter (Fig. 4p, q, Supplementary Fig. 4e–n). The gene discussed is UBE2I; the disease is non-small cell lung carcinoma.