The results showed that mutating K108 residue of hnRNPA2B1 to inhibit hnRNPA2B1 SUMOylation significantly suppressed the ability of circTLCD4-RWDD3-overexpressing NSCLC cells-derived EVs to induce the tube formation and migration of HLECs compared with the control (Supplementary Fig. 6e). The gene discussed is HNRNPA2B1; the disease is non-small cell lung carcinoma.