Moreover, ChIP assays showed that EVs from NSCLC cells overexpressing circTLCD4-RWDD3 led to significantly higher levels of hnRNPA2B1 and H3K4me3 at the PROX1 promoter in HLECs than EVs from NSCLC cells expressing normal levels of circTLCD4-RWDD3 (Fig. 7h, i, Supplementary Fig. 5n–s), indicating that EV-packaged circTLCD4-RWDD3 increased hnRNPA2B1-induced H3K4me3 levels at the PROX1 promoter in HLECs. The gene discussed is PROX1; the disease is non-small cell lung carcinoma.