Unlike the previous study that hnRNPA2B1 was modified by SUMO1 at K108 site,17 we demonstrated that hnRNPA2B1 in NSCLC cells was modified at the K108 site with SUMO2, which mediated the interaction of hnRNPA2B1 with the SIM in ALIX and activated ALIX to recruit ESCRT-III, thus facilitating the packaging of circTLCD4-RWDD3 into EVs. This evidence concerns the gene HNRNPA2B1 and non-small cell lung carcinoma.