HNRNPA2B1 and cancer: SUMOylation is a dynamic and reversible biological event that possesses ability to amplify the effects and signals of targeting proteins through cascade reaction.25 Instead, it has been reported that hnRNPA2B1 was widely modified with SUMO modifiers, thus allowing it to engage in diverse biological functions during cancer progression.17,40 Consistently, we found that SUMOylation of hnRNPA2B1 was essential for the packaging of circTLCD4-RWDD3 into NSCLC-derived EVs in the present study.