PROX1 and non-small cell lung carcinoma: Moreover, western blotting analysis showed that PROX1 expression was elevated in A549- or H1299-EVcircTLCD4-RWDD3 group compared with the control, while HLECs treated with EVs derived from circTLCD4-RWDD3-downregulating NSCLC cells exhibited attenuated PROX1 expression compared with the control group (Fig. 7b, c, Supplementary Fig. 5j, k).