PROX1 and non-small cell lung carcinoma: The essential role of PROX1 in the lymphangiogenesis stimulated by EV-packaged circTLCD4-RWDD3 was confirmed by showing that knocking down of PROX1 strongly weakened the lymphangiogenesis induced by EVs from NSCLC cells overexpressing the circTLCD4-RWDD3 (Fig. 7j–l, Supplementary Fig. 6a–d).