PROX1 and non-small cell lung carcinoma: Subsequently, EV-packaged circTLCD4-RWDD3 was internalized by HLECs to facilitate PROX1 expression by interacting with the nucleotides −1057 to −1048 of PROX1 promoter to induce hnRNPA2B1-mediated H3K4me3, thereby enhancing lymphangiogenesis in NSCLC.