Moreover, the Pearson correlation coefficient between hnRNPA2B1 and late endosome markers significantly increased upon upregulation of circTLCD4-RWDD3 expression in NSCLC cells, while overexpression of SENP3 markedly reduced this elevation induced by circTLCD4-RWDD3 overexpression (Fig. 5i), indicating that the sorting of hnRNPA2B1 into EVs might occur during ALIX-involved formation of late endosome and is regulated by circTLCD4-RWDD3-mediated SUMOylation. This evidence concerns the gene SENP3 and non-small cell lung carcinoma.