BBOX1-AS1 demonstrates upregulation in a wide range of human tumors (Fig. 1), including pituitary adenoma (PA) [34], oral squamous cell carcinoma (OSCC) [35], nasopharyngeal carcinoma (NPC) [36, 37], non-small cell lung cancer (NSCLC) [38–40], esophageal carcinoma (EC) [41–45], hepatocellular carcinoma (HCC) [46, 47], gastric cancer (GC) [48], colorectal cancer (CRC) [49, 50], ovarian cancer (OC) [51], and cervical cancer (CC) [52, 53]. This evidence concerns the gene BBOX1 and oral cavity squamous cell carcinoma.