Molecular subtypes of breast cancer include luminal A (ER + , PR + , -HER2), luminal B (ER + or PR + , + HER2), HER2 enriched (ER- or PR-, + HER2) and triple negative breast cancer (ER- or PR-, -HER2) [5, 6]. This evidence concerns the gene ESR1 and triple-negative breast carcinoma.