The areas under the ROC curve of AXL, SCG5, DCBLD2, VOPP1, DRAM1, DUSP1, AQP5, and BLNK in the detection of oral squamous cell carcinoma were 0.764, 0.907, 0.858, 0.860, 0.767, 0.725, 0.725 and 0.708, respectively. The gene discussed is AQP5; the disease is oral cavity squamous cell carcinoma.