The areas under the ROC curve of AXL, SCG5, DCBLD2, VOPP1, DRAM1, DUSP1, AQP5, and BLNK in the detection of oral squamous cell carcinoma were 0.764, 0.907, 0.858, 0.860, 0.767, 0.725, 0.725 and 0.708, respectively. This evidence concerns the gene DUSP1 and oral cavity squamous cell carcinoma.