The outcomes illustrated a positive correlation between high CENPB protein expression and age (P=0.036), tumor size (P<0.001), TNM staging (P=0.014), serum AFP levels (P=0.015), multiple nodules (P=0.015), vascular invasion (P=0.037), tumor encapsulation (P<0.001), tumor recurrence (P<0.001), and survival status (P<0.001) (Table 3). This evidence concerns the gene CENPB and neoplasm.