The findings demonstrated that elevated expression of CENPB protein was linked to inferior OS and RFS in patients exhibiting low tumor staging (Stage I+II, Figure 3A, 3B), AFP levels below 400ng/ml (Figure 3C, 3D), tumor diameter less than 5cm (Figure 3E, 3F), without of liver cirrhosis (Figure 3G, 3H), free of vascular invasion (FVI, Figure 3I, 3J), and moderate/well differentiation (Figure 3K, 3L). Here, CENPB is linked to cirrhosis of liver.