Although RAD51 has historically been recognized as a key recombinase in the strand exchange process during HR, four heterozygous RAD51 mutations—RAD51-T131P, RAD51-A293T, RAD51-Q242R, and RAD51-A294T—have recently been found to cause an FA-like phenotype, designated as FANCR (26, 27, 28, 29, 30). This evidence concerns the gene RAD51 and Friedreich ataxia.