Two other known FA-related mutations in RAD51, T131P, and A293T are predicted to be located near the interface of RAD51 protomers forming the ATPase active center (Fig. 1C) (34), and RAD51-T131P and RAD51-A293T proteins showed abnormal ATPase activities (26, 27, 30). The gene discussed is RAD51; the disease is Friedreich ataxia.