To the best of our knowledge, the remaining “false positive” cases are described in pediatric and young adult patients, thus comprising a younger population than the one studied by Patel and colleagues in 2017.3 In addition, this group includes pediatric-type gliomas, such as pilocytic and pilomyxoid astrocytoma, diffuse midline gliomas H3K27-altered, MYB/MYBL1-altered diffuse astrocytoma, low-grade astrocytoma, diffuse astrocytoma, angiocentric glioma, DNET, other glioneuronal tumors, as well as gray matter heterotopia. Here, MYBL1 is linked to diffuse astrocytoma.