IFNG and neoplasm: CD276.V-CAR T cells (276.MG.28HD/TM.28CSD.3ζ), were the most effective in killing FN-RMS RD and FP-RMS Rh4 cells in vitro and released the highest levels of IFN-γ and Granzyme B. CD276.V-CAR T cells were able to eradicate CD276high Rh4 tumors in vivo and persisted even after tumor elimination.