CD276 and neoplasm: In order to test CD276-CAR T cells activity in vivo against tumor cells expressing lower levels of CD276, and to investigate the effect of combining CD276/F8-FR4.V Dual-CAR T cells, the same experimental groups of CAR T cells described above (Fig. 13) were investigated in JR cells (CD276lowFGFR4high) expressing low levels of CD276 (7′964, Fig. 1C) and medium–high levels of FGFR4 (3′133, Fig. 2C).