TNFRSF4 and metastatic malignant neoplasm in the lymph nodes: In our analysis, OX40 was the only immune marker that was significantly associated with an aggressive tumor behavior, such as a higher risk of lymph node metastasis and an advanced anatomic stage both in TCs and ICs (in TCs: p = 0.011 and p < 0.001; in ICs: p = 0.040 and p = 0.003, respectively).