APOE and Cognitive impairment: To achieve the goals, the group comparisons between participants stratified by brain amyloid status and cognitive impairment or apolipoprotein E (APOE) genotype were conducted; the association of proteins with ATN markers, cognition, and demographical variables including age, sex, and education were evaluated; and the capabilities of these proteins in predicting future functional decline or brain amyloid positivity were tested.