Other novel pathways are discovered from time to time, interestingly, deficiency of the circadian locomotor output cycles protein kaput (CLOCK) gene in atherosclerotic plaques has been shown to promote EndMT via upregulation of rho-associated coiled-coil-containing protein kinase 1 (ROCK1) [56], which had been previously identified as a promoter of glomerular EndMT in diabetic nephropathy [57], and which has been reported to be indirectly regulated by lncRNA ZFAS1 in renal mesangial cells [58]. Here, CLOCK is linked to diabetic kidney disease.