C Fu et al. demonstrated that knocking down RGS12 in oral squamous cell carcinoma significantly increased cancer cell proliferation and migration in transgenic mice and that RGS12 can inactivate the AKT/mTOR signalling pathway, thereby inhibiting tumour cell development [110] (Figs. 4 and 5, Table 1). This evidence concerns the gene RGS12 and neoplasm.