RGS1, an important member of the R4 RGS subfamily, has been shown to be associated with a variety of B-cell activation and B-cell chemokine regulatory induction signals [118], which are involved mainly in the immune response, interfering with the normal clearance function of lymphocytes, creating an immune escape, and providing a favourable microenvironment for the development of tumour cells [32]. The gene discussed is PITX2; the disease is neoplasm.