Additionally, to further confirm whether circRHOT1 promotes breast cancer progression through the miR-204-5p/PRMT5 axis, we overexpressed PRMT5 in MCF-7 cells and then treated the cells with exosomes derived from MCF-7 cells transfected with si-circRHOT1 or si-NC. The gene discussed is PRMT5; the disease is breast carcinoma.