Given that Mct8KO mice replicate the peripheral hyperthyroidism but do not show the neurological alterations present in AHDS patients due to the mouse-specific compensatory mechanism based on the alternative T4 transporter organic anion transporter 1c1 (OATP1C1) and the enzyme DIO2, the Mct8/Dio2KO mice represent a more faithful model for the disease. Here, SLC16A2 is linked to hyperthyroidism.