In tumor tissues, mRNA expressions of hexokinase 1 (HK1), glucose-6-phosphate isomerase (GPI), fructose-bisphosphatase 1 (FBP1), phosphofructokinase, platelet (PFKP), aldolase, fructose-bisphosphate A (ALDOA), and phosphoglycerate kinase 1 (PGK1) all showed robust circadian rhythms in the control and TRF groups, except that mRNA expressions of HK1 showed acyclic expression in the control group (Fig. 4D–I). The gene discussed is HK1; the disease is neoplasm.