ALDOA and neoplasm: In tumor tissues, mRNA expressions of hexokinase 1 (HK1), glucose-6-phosphate isomerase (GPI), fructose-bisphosphatase 1 (FBP1), phosphofructokinase, platelet (PFKP), aldolase, fructose-bisphosphate A (ALDOA), and phosphoglycerate kinase 1 (PGK1) all showed robust circadian rhythms in the control and TRF groups, except that mRNA expressions of HK1 showed acyclic expression in the control group (Fig. 4D–I).