In the tumor tissue, CRY1, TIM, and GPER1 expressions showed circadian rhythms in both the control and the TRF groups, but the circadian rhythm of TIM expression was more robust in the TRF group, while CRY2 were acyclic in the control group and FBXL3 were acyclic in the TRF group (Fig. 5H–L, M, N). The gene discussed is CRY2; the disease is neoplasm.