We then examined the temporal expression of the five clock genes in four distinct human lung adenocarcinoma cell lines and one human large cell lung cancer cell line at 4-h intervals over a 24-h period (ZT1, 5, 9, 13, 17, and 21), and analyzed their rhythmicity by circacompare (Fig. 5A–F, M, N, and Additional file 1: Table S5, 6). The gene discussed is CLOCK; the disease is lung adenocarcinoma.