According to Gold's research [9], patients with depression have a dysregulated CRH/HPA axis, and hypersecretion of CRH can cause sustained hypercortisolism and excessive activation of the sympathetic nervous system, both of which exacerbate lower urinary tract symptoms due to BPH by affecting urethral smooth muscle via sympathetic innervation [20]. The gene discussed is CRH; the disease is depressive symptom measurement.