GSEA analysis showed that CAD group is characterized by depletion in interferon signaling-related pathways, including interferon gamma signaling pathway and interferon alpha/beta signaling pathway, and is enriched in several immune-regulated and inflammation-related pathways, including TNFs bind their physiological receptors, Rap1 signaling, and TNFR2 non-canonical NF-kB pathway (Fig. 4b). This evidence concerns the gene IFNG and coronary artery disorder.