The first Acromegaly Consensus Conference held in 1999 in Cortina, Italy, concluded that a diagnosis of acromegaly is excluded if random GH is < 0.4 μg/L and age- and sex-matched IGF-I is normal, or if GH nadir is < 1 μg/L during 75-g oral glucose tolerance test (OGTT) and IGF-I is normal [3]. The gene discussed is IGF1; the disease is acromegaly.