APPL1 and early-onset autosomal dominant Alzheimer disease: The analysis of nsSNPs related to APPl protein in the fruit fly showed predicted pathogenic nsSNPs (V94F, V94L, A758G, A758V, and A820G) that could be used for further studies on the induction of familial forms of early-onset Alzheimer's disease and cerebral amyloid angiopathy, and study the factors that increase total Aβ levels42,43.