The authors developed a vascularized, perfused lung-on-a-chip, as well as colon and duodenum intestine chips with HeLa included as a cancer cell line, to examine cell toxicity in response to low- or high-affinity T cell bispecific antibodies (TCBs) targeting folate receptor (FOLR-1) and carcinoembryonic antigen (CEA), in healthy vs. tumor tissue. This evidence concerns the gene CEACAM5 and neoplasm.