A pertinent positive control association is HLA-B*27:05, an allele used for diagnosis and prognostication in clinical medicine38, and which was highly associated with ankylosing spondylitis (OR: 6.55, 95% CI: 5.97–7.18, p: 1.97 × 10−305, effect allele frequency [EAF]: 3.9%). Here, HLA-B is linked to ankylosing spondylitis.