AD susceptibility overall or from the APOE region did not have significant effects on IL6 levels as measured by SomaScan based on Bonferroni-corrected threshold (IVW MRE genome-wide beta = −0.019, p = 5.7E-2; APOE region beta = −0.024, p = 3.9E-1). The gene discussed is APOE; the disease is Alzheimer disease.