Colocalization analyses within the 500 kb region on both sides of the NECTIN2 promoter, which included the APOE gene, did not support a single shared causal variant underlying NECTIN2 protein levels and AD susceptibility (PP of H4: 2.0E-11, Supplementary Data 28), but did support the H3 hypothesis that both traits are associated, but with different causal variants (H3 > 0.9) (Supplementary Fig. 15). Here, APOE is linked to Alzheimer disease.