BMI1 and hepatocellular carcinoma: Finally, we showed that the HCC patients with high expression of TIC-related protein/gene signature and BMI1 had poor overall survival as compared to the patients with low TIC-related protein/gene signature and BMI1 expression (Fig. 1l, m), whilst the overall survival rate of HCC patients accompanied BDTT and high TIC-related protein signature expression was lower than those patients without BDTT and low TIC-related protein signature expression (Supplementary Fig. 1g).