CD8A and neoplasm: These differentiating cell types appear to be consistent with the current understanding that hot or immune-inflamed TME, which has favorable prognosis and is responsive to immunotherapy, is infiltrated with cytotoxic T cells (CD8 positive T cells), NK cells, and M1 macrophages, whereas cold TME is filled with immunosuppressive lymphocytes like regulatory T cells and tumor-associated macrophages (TAM), M0 and M228.