The results showed that LSD1 inhibitor dramatically decreased the protein and mRNA level of ATF4 only in A549 and H1975 cells (Fig. 5A, B), which is consistent with the result that ORY affected xCT expression in sensitive NSCLC cell lines (Fig. 4D and Supplementary Fig. 5B, C). Here, SLC7A11 is linked to non-small cell lung carcinoma.