Moreover, UHRF1, which is an epigenetic driver of mesothelioma, has previously been observed as a potential druggable target30; we found the presence of proteins related to extracellular matrix (ECM), such as cytokeratins which are particularly useful in the diagnosis of MPM, since all mesotheliomas potentially show high expression31–33, and VIM which is highly expressed in up to 75% of malignant mesotheliomas34. The gene discussed is UHRF1; the disease is mesothelioma.