The role of sex hormones in uterine epithelial changes and in the development of pyometra could be affected by CLCa loss through alterations in membrane traffic of the GPCRs that respond to these hormones, such as gonadotropin-releasing hormone receptor, follicle-stimulating hormone receptor, and luteinizing hormone receptor (49, 50). The gene discussed is LHCGR; the disease is pyometritis.