Analysis of E-cadherin, ZO-1, and actin distribution in Ishikawa cysts depleted of CLCb showed that some apico-basal polarity was attained in these cysts, with E-cadherin showing a degree of basolateral distribution, and greater symmetry observed across the cyst than for CLCa-depleted cysts (Fig 7C). The gene discussed is CDH1; the disease is cyst.