We then studied whether the above mechanisms were also operant in cancer cells, where hERG1 is constitutively overexpressed and the hERG1/β1 integrin complex is present (Cherubini et al, 2005; Crociani et al, 2013; Lastraioli et al, 2015, see also Figs 6E and S6). The gene discussed is KCNH2; the disease is cancer.