Consistently, scDb–hERG1–β1 produced significantly higher effects than E4031 in impairing hERG1 translocation to the plasma membrane (Fig 8D), and β1 integrin co-localization with Gαi3 (Fig 8E) and girdin (Fig 8F) in both cancer cell types (Fig S8B–D). This evidence concerns the gene KCNH2 and cancer.