Besides FAT1, SGMs of the APOBEC signature were also seen in other hallmark cancer genes such CDH1, TP53, CDKN2A, and TGFBR2, and putative cancer genes such as the receptor tyrosine kinase EPHA2 that regulates glutamine metabolism in cancer through the Hippo pathway (35). The gene discussed is CDKN2A; the disease is cancer.