SBS signatures have been linked to clock-like mutational processes of aging (6), deficiencies in DNA repair pathways (7), endogenous mutational processes such as the activity of APOBEC cytidine deaminases (8), environmental carcinogens such as ultraviolet (UV) light (9), lifestyle exposures such as tobacco smoking (10), dietary components such as aristolochic acid (11), as well as the effects of cancer therapies (12, 13). Here, CLOCK is linked to cancer.