All analyses were adjusted for age, sex, smoking, drinking, BMI, duration of diabetes, PP, TC, LDL-C, HDL-C, APOA/APOB, ALB, PA, GLO, HBG, PLT, WBC, RBC, NEUT#, ALT, CREA, URIC, HbA1c%, CRP, fenofibrate agents, statin drugs, insulin, insulin secretagogues, biguanides, glycosidase inhibitors, thiazolidinediones and DPP4 inhibitor except for the stratified variables. This evidence concerns the gene INS and diabetes mellitus.