After adjustment for age, sex, smoking, drinking, BMI, duration of diabetes, PP, TC, LDL-C, HDL-C, APOA/APOB, ALB, PA, GLO, HBG, PLT, WBC, RBC, NEUT#, ALT, CREA, URIC, HbA1c%, CRP, fenofibrate agents, statin drugs, insulin, insulin secretagogues, biguanides, glycosidase inhibitors, thiazolidinediones and DPP4 inhibitor in Model 4, the TyG index was still inversely associated with the risk of DF in the Q2 group (OR 0.75; 95% CI 0.60, 0.93), Q3 group (OR 0.58; 95% CI 0.45, 0.75), and Q4 group (OR 0.40; 0.28, 0.55) respectively. This evidence concerns the gene INS and diabetes mellitus.