Similar biosensor–modulator pairs could easilybe tested in the future, such as cyclic adenosine monophosphate (cAMP)indicators54 to study variants of GNAS55 in pseudohypoparathyroidism, or pyruvate sensors56 to study variants in PDHA1 involved in pyruvatedehydrogenase complex deficiency.57 This evidence concerns the gene PDHA1 and pseudohypoparathyroidism type 1A.