These include von Willebrand factor (previously implicated in CVD), TDP-43 (a protein diagnostic for ALS aggregates), Apolipoproteins A–I and A–IV (serum markers/risk factors for CVD), transthyretin (implicated in both AD and CVD), filamins A and B (implicated in cardiac development), and a variety of microtubule-associated proteins (Supplementary Table 1). The gene discussed is TTR; the disease is Alzheimer disease.