CD133 knockdown and Src inhibitor reduced TAZ levels and fibrosis inducers such as CTGF (connective tissue growth factor), CYR61 (Cysteine Rich Angiogenic Inducer 61) and TGFb1 (Transforming growth factor beta-1) in cholangiocyte organoids and the HCT116 CRC cell line [80]. This evidence concerns the gene CCN2 and colorectal carcinoma.