CD133 knockdown and Src inhibitor reduced TAZ levels and fibrosis inducers such as CTGF (connective tissue growth factor), CYR61 (Cysteine Rich Angiogenic Inducer 61) and TGFb1 (Transforming growth factor beta-1) in cholangiocyte organoids and the HCT116 CRC cell line [80]. The gene discussed is CCN1; the disease is colorectal carcinoma.