Whereas CD133 in hepatocytes mitigates collagen deposition and apoptosis during liver fibrosis, other authors have reported that the CD133-Src-TAZ axis has an opposite effect in bile ductal cells, promoting fibrosis inducers secretion, such as TGFβ1 and CTGF that activate hepatic stellate cells to produce extracellular matrix in a model of diet-induced fibrosis [80]. Here, PROM1 is linked to Hepatic fibrosis.