By contrast, Wang et al. (2019) reported that Aquaporin 3 (AQP3) exhibited an opposite effect on CD133 regulation and stem-like properties in HCC [152]; nevertheless, in this study, Aquaporin-mediated H202 transporting was not evaluated, and AQP3 could have functions independent on mediated H202 intracellular levels, such as glycerol uptake and even its cytoplasmic localization could be associated with an intracellular role [153]. The gene discussed is PROM1; the disease is hepatocellular carcinoma.