In addition, Rossi et al. (2019) reported that non-tumoral cells, such as endothelial colony-forming cells (ECFCs), characterized by lacking CD133 in their cell surface, exhibit CD133 intracellular expression, which was associated with revascularization potential after hind limb ischemia in contrast to mature endothelial cells [16]. Here, PROM1 is linked to limb ischemia.