PROM1 and neoplasm: Kim et al. (2021) reported that IL6/IL8 secreted by myofibroblasts in CRC microenvironment increased CD133 + /CD44 + cell subpopulation [180] probably through STAT3/Jagged1 axis that triggers Notch signaling activation in tumor-adjacent cells [193] which has shown to regulate positively CD133 expression [194, 195].