As well, PFKFB (6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase-3), a key glycolytic enzyme, has been reported to maintain CD133 expression, promote cell cycle progression, cancer stemness, and apoptosis evasion in some cancers via dependent and independent way of its glycolytic activity [37–39]. Here, PFKFB3 is linked to cancer.