CD133 upregulation correlated with increased levels of H3K27ac and H3K4me3 on P1, P2, and P3 promoters as well as high levels of histone acetyltransferases P300/CBP-associated factor (PACF) and H3K27me3 demethylase (HDM6B) along with reduced levels of H3K4me3 demethylase (LSD1) in LoVo colon-rectal cancer cell line that overexpressed Aldehyde oxidase 1 (AOX1) [56]. This evidence concerns the gene AOX1 and rectal cancer.