However, due to the limitations of subcellular structure-based protein function in this study, it will be interesting to address the roles of H3cit-positive macrophages through the phagocyte NADPH oxidase complex-derived ROS release, apoptotic cell clearance, cytosolic DNA sensing and type I interferon production, to identify the effects of P140 peptides in lupus at details, and to exclude other types of lung involvement such as pulmonary vascular disease, bronchiolitis, and other airspace abnormalities in the next future. The gene discussed is FMO5; the disease is systemic lupus erythematosus.