However, another study reported that G1 can mediate anti-proliferative and pro-apoptotic effects of oxidants and antioxidant molecules on A549 cells [24] and that GPER1 activation can also inhibit migration of human NSCLC cells by suppressing IKK-β/NF-κB signalling [25]. The gene discussed is GPER1; the disease is non-small cell lung carcinoma.