Our results showed that low GPER1 expression was associated with poor prognosis in BRCA, DLBC, ESCA, HNSC, KIRC, KIRP, LUAD, PAAD, SARC and UCEC, whereas high GPER1 expression was associated with poor prognosis in STAD. The gene discussed is GPER1; the disease is pancreatic adenocarcinoma.