Of significance, AP2A1, AP2B1 and AP2M1 were highly expressed in papillary thyroid cancer (PTC) with the more aggressive BRAF-like gene signature compared to RAS-like PTC (Fig. 3A), as well as in the independent PTC dataset GSE60542 (Fig. 3B). Here, BRAF is linked to thyroid gland papillary carcinoma.