Stratification of papillary thyroid cancer (THCA) TCGA expression data using quartile values (Q3Q4 vs Q1Q2) further highlighted the potential clinical relevance for 5 of these NIS interactors (AP2A2, ARF6, CTTN, HLA-A and RAB5C) on disease recurrence following RAI treatment (P < 0.05; Fig. 1B; Supp Fig. S2A and S2B). This evidence concerns the gene AP2A2 and thyroid gland papillary carcinoma.