CYBB and cancer: Upregulated expression of NOX2 mRNA and correspondingly high levels of ROS have been reported in the spinal cords of mice with sciatic nerve transection (SNT), SCI and cancer-induced bone pain, as well as in the DRG of SNI mice, and global knockout or pharmacological inhibition of NOX2 significantly suppresses established pain [16, 37, 154, 155].