ERBB2 and neoplasm: The mechanisms of action of Tmab in HER2+ tumor elimination mainly fall into three categories: 1) blockade of the surface HER2 receptor on tumor cells (Yarden, 2001); 2) disappearance of the HER2 receptor on the cell surface after endocytosis (Maadi et al., 2021); 3) antibody-dependent cell-mediated cytotoxicity (ADCC) and phagocytosis (ADCP) (Su et al., 2018).