BDNF and Anxiety: WD-associated anxiety-like behavior is accompanied by increased expression of 5HT-r1a and GABAa alpha2 receptor subunit in the ventral HPC (65), as well as elevated brain-derived neurotrophic factor (BDNF) expression in the dorsal HPC (66), a region where BDNF levels correlate with the magnitude of anxiety-like behavior in the elevated plus maze (EPM) task in wildtype mice (67).